Mission

Our goal is to understand, model, and recapitulate in vitro the instructive signals utilized by human embryos to pattern tissue-specific differentiation of pluripotent stem cells, and apply this knowledge towards the rational design of tissue engineered scaffolds and other regenerative therapeutic strategies. Currently, we primarily focus on generating tissues and therapies for the central nervous system.

Recent Publications

Fabricating Complex Culture Substrates Using Robotic Microcontact Printing (R-μCP) and Sequential Nucleophilic Substitution
Gavin T. Knight, Tyler Klann, Jason D. McNulty, Randolph Scott Ashton (2014)
JOVE (92), e52186

Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors
Ethan Scott Lippmann, Maria Carolina Estevez‐Silva, Randolph Scott Ashton (2014)
Stem Cells 32 (4), 1032-1042

Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes
Max R Salick, Brett N Napiwocki, Jin Sha, Gavin T Knight, Shahzad A Chindhy, Timothy J Kamp, Randolph S Ashton, Wendy C Crone (2014)
Biomaterials 35 (15), 4454-4464

More Publications

 

  • Science Photo
  • Science Photo
  • Science Photo
  • Photo of Cardiomyocyte Bucky
  • Photo of Neural Rosette
  • Photo of Micropatterned Molecules
  • Photo showing E6 Method
  • Photo demonstrating a Reaction
  • Link to YouTube Video

Announcements

October 2014
Gavin Knight and Tyler Klann publish an article on "Fabricating Complex Culture Substrates Using Robotic Microcontact Printing (R-µCP) and Sequential Nucleophilic Substitution" in the Journal of Visualized Experiments (JOVE).

Dr. Ethan Lippmann presents a poster on "Deterministic HOX Patterning in Human Pluripotent Stem Cell-derived Posterior Neuroectoderm" at the Biomedical Engineering Society's 2014 Annual Meeting. 

Jason McNulty delivers a talk on "Robotic Microcontact Printing (R-µCP)" at the Biomedical Engineering Society's 2014 Annual Meeting. 

Randolph Ashton delivers an invited lecture entitled, "Engineering Next Generation CNS Tissue Models" at the American Chemical Society's River Rock Regional Section Meeting at Rockford University (Rockford, IL).   

September 2014
Congratulations to Gavin Knight for winning a $1000 travel grant for his winning poster, "Spatiotemporal control of neural stem cell adhesion and migration on RGD-modified PEG brushes", at the 2014 UW Madison SCRMC Fall Conference. 

Congratulations to Jason McNulty for successfully completing his PhD Qualifier examinations.