Our goal is to understand, model, and recapitulate in vitro the instructive signals utilized by human embryos to pattern tissue-specific differentiation of pluripotent stem cells, and apply this knowledge towards the rational design of tissue engineered scaffolds and other regenerative therapeutic strategies. Currently, we primarily focus on generating tissues and therapies for the central nervous system.

Recent Publications

ES Lippmann, MC Estevez-Silva, RS Ashton (2015)
Protocol Exchange [doi:10.1038/protex.2015.076]

Harkness. T., McNulty, J.D., Prestil, R., Seymour, S.K., Klann, T., Murrell, M., Ashton, R. S. and Saha, K. (2015)
Biotechnology Journal. doi: 10.1002/biot.201400756
ES Lippmann, CE Williams, DA Ruhl, MC Estevez-Silva, ER Chapman, JJ Coon, RS Ashton (2015)
Stem Cell Reports, 4(4): 632-44

Knight GT, Sha J, Ashton RS (2015)
Chemical Communications, 51(25): 5238-5241

  • Science Photo
  • Science Photo
  • Science Photo
  • Photo of Cardiomyocyte Bucky
  • Photo of Neural Rosette
  • Photo of Micropatterned Molecules
  • Photo showing E6 Method
  • Photo demonstrating a Reaction
  • Link to YouTube Video


August – November 2015
The Ashton lab publishes a detailed HOX patterning protocol on Nature's Protocol Exchange

Gavin Knight delivers a talk on "Micropatterned Substrates for Spatiotemporal Control of Neural Tissue Morphogenesis" at the 2015 Biomedical Engineering Society Annual Meeting (October)

Randolph Ashton delivers a talk on "Region-specific Cells and Tissue Models for Hindbrain & Spinal Cord Regenerative Medicine" at the Waisman Center and Allen Institute Neuroscience Symposium (16 October)

Randolph Ashton delivers a webinar on "Brain Models for Analysis of Pathways (BRAIN MAPS)" at the Environmental Protection Agency’s National Center for Computational Toxicology, Virtual Tissue Models Meeting  (14 October)

Randolph Ashton delivers a talk on "Engineering Hindbrain and Spinal Cord Tissues for Toxicology and Regenerative Medicine" at Hampton University's 2nd Annual Engineering Alumni Research Symposium (October)

The Ashton Group welcomes Katherine Jeffris and Maria Estevez-Silva as new graduate students to the SCBRM lab. 

The Ashton Group welcomes Kristen Lemke to the group as a new undergraduate research assistant in the SCBRM lab.