Our goal is to understand, model, and recapitulate in vitro the instructive signals utilized by human embryos to pattern tissue-specific differentiation of pluripotent stem cells, and apply this knowledge towards the rational design of tissue engineered scaffolds and other regenerative therapeutic strategies. Currently, we primarily focus on generating tissues and therapies for the central nervous system.
Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors
Ethan Scott Lippmann, Maria Carolina Estevez‐Silva, Randolph Scott Ashton (2014)
Stem Cells 32 (4), 1032-1042
Micropattern width dependent sarcomere development in human ESC-derived cardiomyocytes
Max R Salick, Brett N Napiwocki, Jin Sha, Gavin T Knight, Shahzad A Chindhy, Timothy J Kamp, Randolph S Ashton, Wendy C Crone (2014)
Biomaterials 35 (15), 4454-4464
High-precision robotic microcontact printing (R-μCP) utilizing a vision guided selectively compliant articulated robotic arm
McNulty, J. D., Klann, T., Sha, J., Salick, M., Knight, G. T., Turng, L.-S., & Ashton, R. S. (2014)
Lab Chip 14 (11), 1923-30
Ashton Group In The News
- Ashton, Saha receive Innovation in Regulatory Science Award
- Focus on new faculty: Ashton works to move medicine from treatment to cure
- BMES research group honors Ashton and Saha as ‘rising stars’ in tissue engineering research
- The language of stem cells, decoded
- A paradigm-shifting step in stem cell research
- Seely on Science: Twisted path to understanding stem cells
Congratulation to Professor Gordon Mitchell (co-PI) and Assistant Professor Randolph Ashton (co-PI) for receiving an ICTR Basic and Clinical Research Award on “Phrenic Motor Neuron Derivation and Transplantation” for $50,000. See announcement in the latest ICTR Newsletter.
Randolph Ashton selected to present a seminar entitled, “Engineering next-generation CNS tissue models” at UW Madison’s Stem Cell and Regenerative Medicine Center’s Fall Conference on September 12th, 2014 in the WID-Deluca Forum.
Congratulations to Assistant Professors Randolph Ashton (PI) and Krishanu Saha (Co-I) for receiving a Burroughs Welcome Fund Innovation in Regulatory Sciences Award for $500,000.”